Product Name	FNDC5
Chinese Name	Ⅲ型纤维连接蛋白域蛋白2/5抗体
Alias	Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; FNDC5_HUMAN; FRCP2; Irisin.
literatures	Specific References  (10)     |     SL8486R has been referenced in 10 publications. [IF=7.31] Chen Taiqiu. et al. Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling. OXID MED CELL LONGEV. 2022;2022:9684062  WB ;  Human.   PubMed:35915608 [IF=6.291] Shou-En Wu. et al. Benzo[a]pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species production. ECOTOX ENVIRON SAFE. 2022 Jul;239:113599  WB ;  Mouse.   PubMed:35567930 [IF=6.208] Chuanxi Tang. et al. Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson’s Disease. INT J MOL SCI. 2023 Jan;24(9):7830  WB,CoIP ;  Mouse,Mouse.   PubMed:37175535 [IF=6.081] Daniel Norman. et al. Irisin—A Pancreatic Islet Hormone. Biomedicines. 2022 Feb;10(2):258  IHC ;  Rat,Human.   PubMed:10.3390/biomedicines10020258 [IF=5.895] Guangning Kou. et al. Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway. J AGR FOOD CHEM. 2022;XXXX(XXX):XXX-XXX  IF, IHC, WB ;  Mouse.   PubMed:35708276 [IF=5.314] Zhuoxiao Han. et al. Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. INT J MOL MED. 2023 Apr;51(4):1-18  IHC ;  Mouse.   PubMed:36896789 [IF=4.755] Zhang Lijiao. et al. Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke–induced model of chronic obstructive pulmonary disease. FRONT PHYSIOL. 2022 Aug;0:1600  IF, FC,WB ;  Mouse.   PubMed:36091368 [IF=4.631] Jiao Ma. et al. Irisin Ameliorates PM2.5-Induced Acute Lung Injury by Regulation of Autophagy Through AMPK/mTOR Pathway. J INFLAMM RES. 2023 Mar 10  IF ;  Mouse.   PubMed:36936349 [IF=3.152] Rui Jiao. et al. Irisin Attenuates Fine Particulate Matter Induced Acute Lung Injury by Regulating Nod2/NF-κB Signaling Pathway. IMMUNOBIOLOGY. 2023 Feb;:152358  IF ;  Mouse.   PubMed:10.1016/j.imbio.2023.152358 [IF=2.81] Gao et al. Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes. (2016) PLoS.On. 11:e0147480  WB ;  Mouse.   PubMed:26799325
Research Area	Cell biology  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	12/20kDa
Cellular localization	cytoplasmic The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FNDC5: 81-143/212 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. Function: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. Post-translational modifications: The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. Similarity: Contains 1 fibronectin type-III domain. SWISS: Q8NAU1 Gene ID: 252995 Database links: Entrez Gene: 252995 Human Entrez Gene: 384061 Mouse Entrez Gene: 260327 Rat Omim: 611906 Human SwissProt: Q8NAU1 Human SwissProt: Q8K4Z2 Mouse SwissProt: Q8K3V5 Rat Unigene: 524234 Human Unigene: 44075 Mouse Unigene: 18757 Rat
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug NIH/3T3(Mouse) Cell Lysate at 30 ug K562(Human) Lysate at 30 ug Heart (Mouse) Lysate at 40 ug Primary: Anti-FNDC5   (SL8486R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 12/20 kD Observed band size: 20 kD

Cartpieces

• 
• 9

  9Delete

• 
• 5

  5Delete

• 
• S

  SDelete

• 
• R

  RDelete

• 
• +

  +Delete

• 
• 2

  2Delete

• Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• F

  FDelete

• 
• F

  FDelete

• 

• Delete

• 
• i

  iDelete

• 
• i

  iDelete

• Delete

• 
• 1

  1Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• Delete

• 
• 2

  2Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• Delete

• 
• -

  -Delete

• 
• -

  -Delete

• 
• 0

  0Delete

• Delete

• 
• t

  tDelete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• f

  fDelete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• Delete

• 
• 0

  0Delete

• Delete

• Delete

• Delete

• 
• R

  RDelete

• 
• 5

  5Delete

• 
• A

  ADelete

Totalgoods,subtotals:￥Checkout