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Product Name GHDC Chinese Name GHDC蛋白抗体 Alias D11LGP1; D11LGP1E; D11lgp1e like; GH3 domain containing; GH3 domain containing protein; GH3 domain-containing protein; GHDC; GHDC_HUMAN; Homolog of mouse LGP1; LGP1. Research Area Tumour Cell biology immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 56kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GHDC: 201-300/530 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dubé syndrome and Canavan disease are also associated with chromosome 17.
Subcellular Location:
Endoplasmic reticulum. Nucleus envelope.
Similarity:
Belongs to the GH3 family.
SWISS:
Q8N2G8
Gene ID:
84514
Database links:Entrez Gene: 84514 Human
Entrez Gene: 80860 Mouse
Omim: 608587 Human
SwissProt: Q8N2G8 Human
SwissProt: Q99J23 Mouse
Unigene: 38039 Human
Unigene: 37308 Mouse
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