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Product Name FbxW2 Chinese Name FbxW2蛋白抗体 Alias F box and WD 40 domain containing protein 2; F box and WD repeat domain containing 2; F Box and WD40 Domain Protein 2; F box/WD repeat containing protein 2; FBW 2; FBW2; FBXW 2; Fwd2; Md6; Protein MD6. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 50kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FbxW2: 321-420/454 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail F box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F box proteins have been shown to be critical for the ubiquitin mediated degradation of cellular regulatory proteins. In fact, F box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F box proteins. A large family of mammalian F box proteins has recently been identified and classified into three groups based on the presence of either the WD 40 repeats, the leucine rich repeats, or the presence or absence of other protein protein interacting domains. The FBXW2 gene product, the second identified member of the F box gene family, contains multiple WD 40 repeats.
Subunit:
Directly interacts with SKP1 and CUL1.
Subcellular Location:
Nuclear
Similarity:
Contains 1 F-box domain.
Contains 4 WD repeats.
SWISS:
Q9UKT8
Gene ID:
26190
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