Product Name	UBE2O
Chinese Name	Ubiquitin结合酶E2 230K抗体
Alias	E2 230K; ubiquitin-conjugating enzyme E2O; EC=6.3.2.19; FLJ12878; KIAA1734; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme; RP23 193A16.5; UBE2O; UBE2O_HUMAN; Ubiquitin carrier protein O; Ubiquitin conjugating enzyme E2 O; ubiquitin conjugating enzyme E2O.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Mouse, Rat, Chicken, Pig, Horse, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	141kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human UBE2O/E2 230K: 1201-1292/1292
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Tissue Specificity: Predominantly expressed in skeletal muscle and heart. Similarity: Belongs to the ubiquitin-conjugating enzyme family. SWISS: Q9C0C9 Gene ID: 63893 Database links: Entrez Gene: 63893 Human Entrez Gene: 217342 Mouse SwissProt: Q9C0C9 Human SwissProt: Q6ZPJ3 Mouse Unigene: 16130 Human Unigene: 243950 Mouse

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