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Product Name CA XI Chinese Name 碳酸酐酶11抗体 Alias CA-RP II; CA-RP XI; CA-XI; CA11; CAH11_HUMAN; Carbonic anhydrase-related protein 11; Carbonic anhydrase-related protein 2; CARP XI; CARP-2; CARP2. Research Area Cardiovascular Cell biology immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 34kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CA XI/Carbonic Anhydrase XI: 101-200/328 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide. CAs show extensive diversity in their distribution and subcellular localization. They are involved in a variety of biological processes, including calcification, bone resorption, respiration, acid-base balance and the formation of aqueous humor, saliva, gastric juice and cerebrospinal fluid. CA XI, also referred to as carbonic anhydrase-related protein 11 precursor (CA-RP XI) or carbonic anhydrase-related protein 2 (CA-RP II), is a member of the carbonic anhydrase family that lacks two of the three Zn-binding motifs essential for carbonic anhydrase activity. For this reason, CA XI does not exhibit catalytic activity. It is expressed primarily in brain but is also found in spinal cord and thyroid. CA XI may play a role in brain development.
Tissue specificity:Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.
Function:
Does not have a catalytic activity.
Subcellular Location:
Secreted (Potential).
Tissue Specificity:
Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.
Similarity:
Belongs to the alpha-carbonic anhydrase family.
SWISS:
O75493
Gene ID:
770
Database links:Entrez Gene: 770 Human
Entrez Gene: 12348 Mouse
Omim: 604644 Human
SwissProt: O75493 Human
SwissProt: O70354 Mouse
Unigene: 428446 Human
Unigene: 27736 Mouse
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