Product Name	FAM129B
Chinese Name	FAM129B蛋白抗体
Alias	chromosome 9 open reading frame 88; DKFZP434H0820; FAM129B; family with sequence similarity 129, member B; FLJ13518; FLJ22151; FLJ22298; hypothetical protein LOC64855; Meg 3; Meg-3; Meg3; Niban like protein 1; Niban-like protein 1; NIBL1_HUMAN; OC58; Protein FAM129B; bA356B19.6; C9orf88.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	83kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FAM129B: 284-390/746
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. Subcellular Location: Cytoplasm, cytosol. Cell junction, adherens junction. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation. Post-translational modifications: Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases (PubMed:21148485). Similarity: Belongs to the Niban family. Contains 1 PH domain. SWISS: Q96TA1 Gene ID: 64855 Database links: Entrez Gene: 64855 Human Entrez Gene: 227737 Mouse SwissProt: Q96TA1 Human SwissProt: Q8R1F1 Mouse Unigene: 522401 Human Unigene: 301646 Mouse

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