Product Name	CSMD2
Chinese Name	CSMD2蛋白抗体
Alias	CSMD2_HUMAN; CUB and Sushi (SCR repeat) domain; CUB and sushi domain-containing protein 2; CUB and sushi multiple domains protein 2; dJ1007G16.1; dJ1007G16.2; dJ947L8.1; KIAA1884.
Research Area	Cell biology  immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	380kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CSMD2: 251-350/3487 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The CUB and sushi domain-containing proteins, CSMD1-3, are membrane proteins that are involved in cell-cell adhesion and are weakly expressed in most tissues, with higher levels of expression observed in the cerebellum and hippocampus. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas. CSMD2 and CSMD3 are located primarily in the brain and are implicated in some forms of head and neck cancer. Additionally, the CSMD3 gene is a candidate for induction of epileptic seizures. Subcellular Location: Cell membrane; Single-pass membrane protein (Potential). Tissue Specificity: Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain. Overexpressed in some head and neck cancer cell lines. Similarity: Belongs to the CSMD family. Contains 14 CUB domains. Contains 26 Sushi (CCP/SCR) domains. SWISS: Q7Z408 Gene ID: 114784 Database links: Entrez Gene: 114784 Human Omim: 608398 Human SwissProt: Q7Z408 Human Unigene: 656915 Human
Product Picture	Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti- CSMD2 (SL8187R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 380 kD Observed band size: 380 kD

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