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Product Name SRRM4 Chinese Name 丝氨酸/精氨酸相关核基质蛋白4抗体 Alias Neural-specific serine/arginine repetitive splicing factor of 100 kDa; Neural-specific SR-related protein of 100 kDa; nSR100; Serine/arginine repetitive matrix protein 4; Srrm4; SRRM4_HUMAN. Research Area Cell biology Developmental biology Neurobiology Signal transduction Cyclin Cell differentiation Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 69kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SRRM4: 451-611/611 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts.
Function:
Splicing factor specifically required for neural celldifferentiation. Acts in conjuction with nPTB/PTBP2 by bindingdirectly to its regulated target transcripts and promotesneural-specific exon inclusion in many genes that function inneural cell differentiation. Required to promote the inclusion ofneural-specific exon 10 in nPTB/PTBP2, leading to increasedexpression of neural-specific nPTB/PTBP2. Also promotes theinclusion of exon 16 in DAAM1 in neuron extracts (By similarity).
Subcellular Location:
Nucleus (By similarity).
Tissue Specificity:
Specifically expressed in neuronal cells (atprotein level). Expressed in the cerebellum.
Post-translational modifications:
Phosphorylated (By similarity).
Similarity:
Belongs to the nSR100 family.
SWISS:
A7MD48
Gene ID:
84530
Database links:Entrez Gene: 84530 Human
Entrez Gene: 68955 Mouse
SwissProt: A7MD48 Human
SwissProt: Q8BKA3 Mouse
Unigene: 726207 Human
Unigene: 146779 Mouse
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