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Product Name PLEKHM2 Chinese Name 血小板白细胞C激酶底物同源结构域M2抗体 Alias PH domain containing family M member 2; Pleckstrin homology domain containing family M (with RUN domain) member 2; Pleckstrin homology domain containing family M member 2; PLEKHM 2; RP11 169K16.1; Salmonella induced filaments A and kinesin interacting protein; SifA (Salmonella induced filaments A) and kinesin interacting protein; SifA and kinesin interacting protein; SKIP; KIAA0842; Novel RUN and PH domain containing protein; PKHM2_HUMAN. Research Area Cell biology immunology Bacteria and viruses Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 113kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PLEKHM2: 688-750/1019 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.
Function:
May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.
Subunit:
Interacts with KIF5B. Interacts with the S.typhimurium sifA protein; required for S.typhimurium infection.
Subcellular Location:
Cytoplasm.
Similarity:
Contains 1 PH domain.
Contains 1 RUN domain.
SWISS:
Q8IWE5
Gene ID:
23207
Database links:
Entrez Gene: 23207 Human
Entrez Gene: 69582 Mouse
Omim: 609613 Human
SwissProt: Q8IWE5 Human
SwissProt: Q80TQ5 Mouse
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