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Product Name COMMD7 Chinese Name 铜代谢结构域蛋白7抗体 Alias C20orf92; Chromosome 20 open reading frame 92; COMM domain containing 7; COMM domain containing protein 7; COMMD 7; dJ1085F17.3; FLJ14987; MGC33315; OTTHUMP00000030609; COMD7_HUMAN. Research Area Cell biology Signal transduction Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization The nucleus cytoplasmic Extracellular matrix Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from Human COMMD7: 81-170/200 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail COMMD is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. The prototype of this family, MURR1/COMMD1, suppresses NFkB by affecting the association of NF-kappaB with chromatin. COMMD7 (COMM domain-containing protein 7) interacts with COMMD1 via its COMM domain. It also associates with the NF-kappa-B complex and suppresses its transcriptional activity.
Function:
Associates with the NF-kappa-B complex and suppresses its transcriptional activity.
Subunit:
Interacts (via COMM domain) with COMMD1 (via COMM domain).
Tissue Specificity:
Widely expressed with highest expression in lung.
Similarity:
Contains 1 COMM domain.
SWISS:
Q86VX2
Gene ID:
149951
Database links:
UniProtKB/Swiss-Prot: Q86VX2.2
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