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Product Name CNKSR2/KSR2 Chinese Name Ras激酶抑制因子连接增强蛋白2抗体 Alias CNKR 2; CNK2; CNKSR2; Connector enhancer of kinase suppressor of Ras 2; Connector enhancer of KSR2; KIAA0902; KSR2; RP11 450P7.2; CNKR2_HUMAN. Research Area Cell biology immunology Signal transduction G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 114kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CNKSR2 corresponding to amino acids 863-508.: 481-580/1034 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CNKR2 may function as an adapter protein or regulator of Ras signaling pathways.
Function:
May function as an adapter protein or regulator of Ras signaling pathways.
Subunit:
Interacts with RAF1, RAB2L and RAL GTPase proteins.
Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.
Post-translational modifications:
Phosphorylated on tyrosine.
Similarity:
Belongs to the CNKSR family.
Contains 1 CRIC domain.
Contains 1 DUF1170 domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q8WXI2
Gene ID:
22866
Database links:
Entrez Gene: 22866 Human
Entrez Gene: 245684 Mouse
SwissProt: Q8WXI2 Human
SwissProt: Q80YA9 Mouse
Unigene: 632794 Human
Unigene: 197074 Mouse
Product Picture Sample:
U251(Human) Cell Lysate at 30 ug
Primary: Anti-CNKSR2/KSR2 (SL8029R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114 kD
Observed band size: 114 kD
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CNKSR2/KSR2) Polyclonal Antibody, Unconjugated (SL8029R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CNKSR2/KSR2) Polyclonal Antibody, Unconjugated (SL8029R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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