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Product Name CNKSR1 Chinese Name Ras激酶抑制因子连接增强蛋白1抗体 Alias CNK; CNK homolog protein 1; CNK1; CNKR1_HUMAN; CNKSR1; Connector enhancer of kinase suppressor of ras 1; Connector enhancer of KSR 1; Connector enhancer of KSR like; Connector enhancer of KSR-like; Connector enhancer of KSR1; hCNK1; KSR. Research Area Cell biology immunology Signal transduction G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 80kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CNKSR1: 621-720/720 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008].
Function:
May function as an adapter protein or regulator of Ras signaling pathways.
Subunit:
Interacts with RHO and RALGDS.
Subcellular Location:
Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
Post-translational modifications:
Phosphorylated on tyrosine.
Similarity:
Belongs to the CNKSR family.
Contains 1 CRIC domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q969H4
Gene ID:
10256
Database links:Entrez Gene: 10256 Human
Entrez Gene: 194231 Mouse
Omim: 603272 Human
SwissProt: Q969H4 Human
Unigene: 16232 Human
Unigene: 726160 Human
Unigene: 331958 Mouse
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