Product Name	CCDC52
Chinese Name	卷曲螺旋结构域蛋白52抗体
Alias	Coiled coil domain containing protein 52; Coiled-coil domain-containing protein 52; FLJ26064; FLJ44949; SPICE_HUMAN; spice1; Spindle and centriole-associated protein 1; Spindle and centriole-associated protein.
Research Area	Cell biology  immunology  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Rabbit, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	96kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CCDC52: 51-140/855
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. The gene encoding CCDC52 (Coiled-coil domain-containing protein 52), a 855 amino acid protein, exists on human chromosome 3. Function: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. Subunit: Interacts with CEP120 Subcellular Location: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. SWISS: Q8N0Z3 Gene ID: 152185 Database links: Entrez Gene: 152185 Human Omim: 613447 Human SwissProt: Q8N0Z3 Human Unigene: 477144 Human

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