Product Name	ASNA1
Chinese Name	砷酸盐转运三磷酸腺苷酶抗体
Alias	ARSA 1; ARSA; ArsA arsenite transporter ATP binding homolog 1; ArsA arsenite transporter, ATP binding, E. coli, homolog of, 1; ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ARSA I; ARSA1; ARSAI; Arsenical pump driving ATPase; Arsenical resistance ATPase; Arsenite translocating ATPase; Arsenite transporting ATPase; Arsenite-stimulated ATPase; ASNA 1; ASNA I; Asna1 protein; ASNAI; ATPase Asna1; GET3; ASNA_HUMAN.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ASNA1: 64-155/348
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ASNA1 is the human homolog of the E.coli arsA gene which is an ATPase, and is the catalytic component of a multisubunit oxyanion pump responsible for resistance to arsenicals and antimonials. Function: This gene represents the human homolog of the bacterialarsA gene, encoding the arsenite-stimulated ATPase component of thearsenite transporter responsible for resistance to arsenicals. Thisprotein is also a central component of a transmembrane domain (TMD)recognition complex (TRC) that is involved in thepost-translational delivery of tail-anchored (TA) proteins from thecytosol to the endoplasmic reticulum (ER). It recognizes andselectively binds the TMD of TA proteins in the cytosol, anddelivers them to the ER for insertion. [provided by RefSeq, Oct2011]. [FUNCTION] ATPase required for the post-translational delivery oftail-anchored (TA) proteins to the endoplasmic reticulum.Recognizes and selectively binds the transmembrane domain of TAproteins in the cytosol. This complex then targets to theendoplasmic reticulum by membrane-bound receptors, where thetail-anchored protein is released for insertion. This process isregulated by ATP binding and hydrolysis. ATP binding drives thehomodimer towards the closed dimer state, facilitating recognitionof newly synthesized TA membrane proteins. ATP hydrolysis isrequired for insertion. Subsequently, the homodimer reverts towardsthe open dimer state, lowering its affinity for the membrane-boundreceptor, and returning it to the cytosol to initiate a new roundof targeting (By similarity). May be involved in insulin signaling. Subunit: Homodimer (By similarity). Component of a transmembranedomain recognition complex (TRC) (By similarity). Interacts withSERP1 and SEC61B (By similarity). Interacts with WRB. Subcellular Location: Cytoplasm. Endoplasmic reticulum. Nucleus,nucleolus. Tissue Specificity: Expressed in the epithelial cells of theliver, kidney, and stomach wall, in the adrenal medulla, in theislet cells of the pancreas, in the red pulp of the spleen, and incardiac and skeletal muscle. Similarity: Belongs to the arsA ATPase family. SWISS: O43681 Gene ID: 439 Database links: Entrez Gene: 439 Human Entrez Gene: 56495 Mouse Entrez Gene: 288919 Rat GenBank: NP_004308.2 Human Omim: 601913 Human SwissProt: O43681 Human SwissProt: O54984 Mouse Unigene: 465985 Human Unigene: 41475 Mouse

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