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Product Name NEU4 Chinese Name 神经氨酸酶4抗体 Alias N acetyl alpha neuraminidase 4; Neuraminidase 4; Sialidase 4; NEUR4_HUMAN. Research Area Cell biology Neurobiology Cyclin Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 51kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NEU4: 151-450/484 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail NEU4 belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.
Function:
May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.
Subcellular Location:
Isoform 1: Membrane; Peripheral membrane protein. Isoform 2: Lysosome lumen.
Tissue Specificity:
Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta.
Post-translational modifications:
According to PubMed:15213228, phosphorylation of mannose residues may ensure efficient transport of isoform 2 to the lysosomes via the mannose 6-phosphate receptor.
Isoform 2 is glycosylated (PubMed:15213228).
Similarity:
Belongs to the glycosyl hydrolase 33 family.
Contains 3 BNR repeats.
SWISS:
Q8WWR8
Gene ID:
129807
Database links:
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