Product Name	RGS19
Chinese Name	G protein signal转导调节因子19抗体
Alias	G alpha interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; RGSGAIP; RGS19_HUMAN; Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein.
literatures	Specific References  (1)     |     SL3867R has been referenced in 1 publications. [IF=0] Sakaguchi et al. Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma. (2018) Oncotarget. 9:23003-23017  WB ;  human.   PubMed:29796168
Research Area	Tumour  immunology  Signal transduction  Apoptosis  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RGS19: /101-200/217
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase activating protein that functions to down regulate Galpha i/Galpha q linked signaling. Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. Subunit: Interacts with GIPC PDZ domain. Subcellular Location: Membrane; Lipid-anchor. Tissue Specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. Post-translational modifications: Fatty acylated. Heavily palmitoylated in the cysteine string motif. Phosphorylated, mainly on serine residues. Similarity: Contains 1 RGS domain. SWISS: P49795 Gene ID: 10287 Database links: UniProtKB/Swiss-Prot: P49795.1

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