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Rabbit Anti-EDNRA antibody
Rabbit Anti-EDNRA antibody
Endothelin receptor type A; EDNRA; Endothelin 1 receptor precursor; EDNR-A; Endothelin A receptor; Endothelin receptor type A; ET A; ETA; ET-A; ETA-R; ETA R; ETRA; hET AR; Ednra; EDNRA_HUMAN; Endothelin 1 specific receptor; Endothelin ET A receptor; Endot
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  • NO.:SL1757R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,Rat,(predicted: Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)
    Applications:WB ELISA IHC-P IHC-F IF
    concentration:1mg/ml
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Product Name EDNRA
Chinese Name 内皮素受体A抗体
Alias Endothelin receptor type A; EDNRA; Endothelin 1 receptor precursor; EDNR-A; Endothelin A receptor; Endothelin receptor type A; ET A; ETA; ET-A; ETA-R; ETA R; ETRA; hET AR; Ednra; EDNRA_HUMAN; Endothelin 1 specific receptor; Endothelin ET A receptor; Endothelin receptor ET1 specific type; Endothelin-1 receptor.  
literatures
Specific References  (3)     |     SL1757R has been referenced in 3 publications.
[IF=2.197] Cheng P et al. Xin-Ji-Er-Kang Alleviates Myocardial Infarction-Induced Cardiovascular Remodeling in Rats by Inhibiting Endothelial Dysfunction. Biomed Res Int. 2019 Jun 25;2019:4794082.  IHF&WB ;  Rat.  
[IF=1.564] Haizhao Zhao. et al. The Influence of Bosentan on MicroRNA-27a/PPARγ/ET-1 Signaling Pathway in Pulmonary Artery Hypertension. 2021 Apr 15  WB ;  Human.  
[IF=0.939] Prayitnaningsih et al. Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats. (2016) Int.J.Ophthalmol. 9:1568-1577  IF(IHC-P) ;  Rat.  
Research Area Cardiovascular  immunology  Growth factors and hormones  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 47kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human EDNRA: 321-427/427 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Subunit:
Interacts with HDAC7 and KAT5.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.

SWISS:
P25101

Gene ID:
1909

Database links:

Entrez Gene: 281749 Cow

Entrez Gene: 450187 Dog

Entrez Gene: 1909 Human

Entrez Gene: 13617 Mouse

Entrez Gene: 397457 Pig

Entrez Gene: 24326 Rat

GenBank: NM_001957 Human

GenBank: NM_174308 Human

GenBank: NM_012550 Rat

Omim: 131243 Human

SwissProt: P21450 Cow

SwissProt: Q5KSU9 Dog

SwissProt: P25101 Human

SwissProt: Q61614 Mouse

SwissProt: Q29010 Pig

SwissProt: P26684 Rat

Unigene: 183713 Human

Unigene: 283168 Mouse

Unigene: 392296 Mouse

Unigene: 10915 Rat



Product Picture
Sample:
Lane 1: Mouse Heart tissue lysates
Lane 2: Rat Cerebrum tissue lysates
Primary: Anti-EDNRA (SL1757R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa

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