Product Name	Tropomodulin 2
Chinese Name	原肌球蛋白调节蛋白1抗体
Alias	MGC39481; N Tmod; TMOD2_HUMAN; Neuronal tropomodulin; NTMOD; TMOD2; tropomodulin 2 (neuronal); Tropomodulin 2; tropomodulin 2 neuronal.
Research Area	Cell biology  Signal transduction  Binding protein  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Tropomodulin 2: 251-351/351
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008] Function: Tropomodulin is the actin-capping protein for the slow growing end of filamentous actin. Tropomodulin 2 is a neuronal specific isoform which is the major binding protein to brain tropomyosin in rat. Subunit: Binds to the N-terminus of tropomyosin and to actin. Subcellular Location: Cytoplasm; cytoskeleton Tissue Specificity: Neuronal-tissue specific. Similarity: Belongs to the tropomodulin family. SWISS: Q9NZR1 Gene ID: 29767 Database links: Entrez Gene: 29767 Human Entrez Gene: 50876 Mouse Entrez Gene: 58814 Rat Omim: 602928 Human SwissProt: Q9NZR1 Human SwissProt: Q9JKK7 Mouse SwissProt: P70566 Rat
Product Picture	Sample: U937(Human) Cell Lysate at 30 ug Primary: Anti- Tropomodulin 2 (SL17155R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 40 kD Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tropomodulin 2) Polyclonal Antibody, Unconjugated (SL17155R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tropomodulin 2) Polyclonal Antibody, Unconjugated (SL17155R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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