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Product Name STX17 Chinese Name 突触17抗体 Alias FLJ20651; MGC102796; MGC126613; MGC126615; Stx17; STX17_HUMAN; Syntaxin 17; Syntaxin-17. Research Area Cell biology immunology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 33kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human STX17: 251-350/302 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain C-terminal hydrophobic domains that direct them to their respective intracellular compartments. Syntaxin 17, also known as STX17, is a 302 amino acid single-pass type IV membrane protein that contains one t-SNARE coiled-coil homology domain and belongs to the syntaxin family. Thought to localize to the endoplasmic reticulum, Syntaxin 17 plays a role in vesicle trafficking to lysosomes and may be involved in processes related to cell division. The gene encoding Syntaxin 17 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
Function:
Implicated in vesicle trafficking to lysosomes. Could be involved in processes related to cell division.
Subcellular Location:
Membrane. Appears to be associated with a membrane compartment, perhaps a subset of the ER such as exit or entrance sites.
Similarity:
Belongs to the syntaxin family.
Contains 1 t-SNARE coiled-coil homology domain.
SWISS:
P56962
Gene ID:
55014
Database links:Entrez Gene: 55014 Human
Omim: 604204 Human
SwissProt: P56962 Human
Unigene: 704031 Human
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