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Product Name Goat Anti-Human IgM Chinese Name 羊抗人IgM Alias Human Immunoglobulin M; hu IgM; 羊抗人-IgM literatures Specific References (2) | SL0345G has been referenced in 2 publications.[IF=3.565] Yuan Y et al. CMTM5-v1 inhibits cell proliferation and migration by downregulating oncogenic EGFR signaling in prostate cancer cells. J Cancer . 2020 Apr 6;11(13):3762-3770. WB ; human.[IF=1.79] Tang, Jieli, et al. "Studies of Fluorescence Immunosensor Using Eggshell Membrane as Immobilization Matrix." Journal of fluorescence 21.1 (2011): 339-346. Human.Immunogen Species Goat Clonality Polyclonal React Species Human, Applications WB=1:1000-5000 ELISA=1:2000-10000 IHC-P=1:200-1000 IHC-F=1:200-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Form Lyophilized powder immunogen Native Human IgM: full length Lsotype IgG Purification Affinity purified by Protein G Storage Store at -20℃ stable for 2 years (lyophilized powder). Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Product Detail IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences.
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