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Product Name Anti-PCSK2/Proprotein Convertase 2/RBITC Chinese Name 罗丹明(RBITC)标记的神经内分泌转化酶2抗体 Alias KEX2 like endoprotease 2; KEX2-like endoprotease 2; NEC 2; NEC2; NEC2_HUMAN; Neuroendocrine convertase 2; PC2; PCSK2; Prohormone convertase 2; Proprotein convertase 2; Proprotein convertase subtilisin/kexin type 2; SPC2. Research Area Cell biology Neurobiology Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Chicken, Dog, Cow, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 58kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Proprotein Convertase 2 (201-300aa) Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Function:
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
Subcellular Location:
Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
Similarity:
Belongs to the peptidase S8 family. Furin subfamily.
Database links:Entrez Gene: 5126 Human
Entrez Gene: 18549 Mouse
Omim: 162151 Human
SwissProt: P16519 Human
SwissProt: P21661 Mouse
Unigene: 315186 Human
Unigene: 294493 Mouse
Unigene: 447466 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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