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Product Name Anti-PNPLA3/PE Chinese Name PE标记的脂肪营养素PNPLA3抗体 Alias Acylglycerol O acyltransferase; Adiponutrin; ADPN; C22orf20; Calcium independent phospholipase A2 epsilon; DJ796I17.1; iPLA(2)epsilon; IPLA2-epsilon; Patatin like phospholipase domain containing 3; patatin like phospholipase domain containing protein 3; phospholipase A2, calcium independent, epsilon. Research Area Tumour Cardiovascular Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 53kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse PNPLA3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
Function:
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.
Subcellular Location:
Membrane; Single pass type II membrane protein.
DISEASE:
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease description:A condition characterized by accumulation of triglycerides in the liver. It is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries.
Similarity:
Contains 1 patatin domain.
Database links:
Entrez Gene: 101131854 Gorilla
Entrez Gene: 101824852 Hamster
Entrez Gene: 80339 Human
Entrez Gene: 100406659 Marmoset (common)
Entrez Gene: 116939 Mouse
Entrez Gene: 100344884 Rabbit
Omim: 609567 Human
SwissProt: Q9NST1 Human
SwissProt: Q91WW7 Mouse
Unigene: 654800 Human
Unigene: 390817 Mouse
Unigene: 97779 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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