Product Name	Anti-SCAPER/PE
Chinese Name	PE标记的SCAPER蛋白抗体
Alias	FLJ31533; FLJ31953; FLJ46212; KIAA1454; MSTP063; S phase cyclin A-associated protein in the endoplasmic reticulum; S phase cyclin A-associated protein in the ER; SCAPE_HUMAN; SCAPER; Zfp291; Zinc finger protein 291; ZNF291.
Research Area
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	158kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SCAPER
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: SCAPER is a 1,399 amino acid protein that contains a C2H2-type zinc finger, a putative transmembrane domain, an ER retrieval signal at the C terminus, four coiled-coil domains, six potential RXL motifs that might confer binding to cyclins and six consensus Cdk phosphorylation sites. SCAPER interacts with, and is phosphorylated in vitro by, the cyclin A/Cdk2 complex at multiple phases of the cell cycle, including S and G2/M. It has been suggested that SCAPER represents a novel cyclin A/Cdk2 regulatory protein that transiently maintains cyclin A in the cytoplasm. The SCAPER protein is predominantly located in the endoplasmic reticulum, with only a small portion detected in the nucleus. Widely expressed, SCAPER demonstrates highest expression in testis. Existing as two alternatively spliced isoforms, the SCAPER gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 15q24.3. Function: CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. Subcellular Location: Endoplasmic reticulum. Nucleus. Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus. Tissue Specificity: Widely expressed with highest expression in testis. Post-translational modifications: Phosphorylated in vitro by the CCNA2/CDK2 complex. Similarity: Contains 1 C2H2-type zinc finger. Database links: Entrez Gene: 49855 Human Entrez Gene: 244891 Mouse Omim: 611611 Human SwissProt: Q9BY12 Human Unigene: 458986 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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