Product Name	Anti-Cocaine(C2F1)/Cy7
Chinese Name	Cy7标记的可卡因单克隆抗体
Alias	Ecgonine methyl ester benzoate hydrochloride.
Product Type	Small molecule anti
Research Area	immunology  Neurobiology  Drugs and Compounds
Immunogen Species	Mouse
Clonality	Polyclonal
Clone NO.	C2F1
React Species
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	0.30335kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Cocaine
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Cocaine is a powerfully addictive stimulant drug. The powdered hydrochloride salt form of cocaine can be snorted or dissolved in water and then injected. Crack is the street name given to the form of cocaine that has been processed to make a rock crystal, which, when heated, produces vapors that are smoked. The term “crack” refers to the crackling sound produced by the rock as it is heated. Inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 可卡因对中枢神经系统产生兴奋作用，是导致滥用的重要原因。兴奋初期，滥用者产生欣快，感到飘飘欲仙、舒适无比，表现洋洋自得、健谈。用药后的兴奋作用，产生了消除疲劳的感觉。这类兴奋感觉只能维持30分钟左右。随之以后，它给人身体的抑制效应便出现了。吸毒者为了恢复初期的体验，往往再用第二剂、厖乃至每10分钟使用一次，以维持?#30270;劲?#19981;致衰落。周而复始，剂量越用越大，使用越来越频繁，把吸食者带到毁灭的深渊。 　　 小剂量的可卡因导致的心律是缓慢的。剂量增大后则心律增快，呼吸急促，可出现呕吐、震颤、痉挛、惊厥等现象。如果大剂量，则可导致死亡。一剂70毫克的纯可卡因，可以使体重70公斤的人当场丧命。 　　 吸毒者滥用可卡因的方式，常用鼻吸法，通过鼻粘膜吸收。这种方式的长期作用，使鼻粘膜部分组织坏死或溃疡；也由于可卡因对鼻粘膜的刺激性，吸毒者常不由自主地挖鼻子，导致鼻中隔穿孔甚至坍塌。用静脉注射方式注射可卡因，其毒性作用可非常迅速直达心脏，给生命带来的危险是非常大的。吸毒者往往使用未经消毒使用注射器，极易造成皮肤脓肿和各种感染。滥用者由于共用针头和注射器，也会感染和传播肝炎和艾滋病病毒。 　　 可卡因成瘾者在高剂量使用可卡因时，出现类偏执性精神病，出现妄想、假性幻觉。在被害妄想的驱使下，把一切人视为敌人，把别人的一举一动都视为对自己的威胁，便采取?#20808;发制人?#12289;攻击他人的行为，伤害他人，危害社会。产生的幻视、幻触，感觉看到而实际没有出现的东西，或感觉身体某一部分有?#34411;子?#38075;进去在涌动的难受，而常常?#37319;取措施?#33258;残肢体。这叫做可卡因中毒性精神病。

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