Product Name	Anti-HPV33 E6/APC
Chinese Name	APC标记的人类乳头状瘤病毒33 E6蛋白抗体
Alias	E6 protein [Human papillomavirus type 33]; Human Papilloma Virus; Human papillomavirus type 33; Human papillomavirus type 33; Protein 33; HPV33-E6 protein; HPV33 E6 protein; VE6_HPV33.
Research Area	Tumour  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	16kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HPV33 E6 protein
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. Function: Transcriptional transactivator. Binds double stranded DNA (By similarity). This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus) Subcellular Location: Host nucleus matrix (By similarity). Similarity: Belongs to the papillomaviridae E6 protein family. Database links: UniProtKB/Swiss-Prot: P06427.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人类乳头状瘤病毒33（HPV33）是导致女性宫颈癌的主要病毒型（包括人类乳头状瘤病毒33）属于高危亚型人类乳头状瘤病毒。

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