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Rabbit Anti-PPHLN1/APC Conjugated antibody
Rabbit Anti-PPHLN1/APC Conjugated antibody
Gastric cancer antigen Ga50; Periphilin 1; Periphilin-1; PPHLN_HUMAN; PPHLN1.
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  • NO.:SL7872R-APC
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)
    Applications:IF
    concentration:1mg/ml
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Details

Product Name Anti-PPHLN1/APC
Chinese Name APC标记的脉周蛋白1抗体(胃癌抗原蛋白Ga50)
Alias Gastric cancer antigen Ga50; Periphilin 1; Periphilin-1; PPHLN_HUMAN; PPHLN1.  
Research Area Cell biology  immunology  Cyclin  Cell differentiation  Cell type markers  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 53kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human PPHLN1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation.

Function:
Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation.

Subunit:
Homodimer. Interacts with PPL.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Substrate of transglutaminase (in vitro).

Database links:
 UniProtKB/Swiss-Prot: Q8NEY8.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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