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Rabbit Anti-CPXM/APC Conjugated antibody
Rabbit Anti-CPXM/APC Conjugated antibody
Carboxypeptidase X (M14 family) member 1; Carboxypeptidase X member 1; CPX 1; CPX1; CPXM 1; CPXM1; Metallocarboxypeptidase CPX 1; Probable carboxypeptidase X1; CPXM1_HUMAN.
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  • NO.:SL8341R-APC
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,)
    Applications:IF
    concentration:1mg/ml
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Details

Product Name Anti-CPXM/APC
Chinese Name APC标记的羧肽酶X(M14家族1)抗体
Alias Carboxypeptidase X (M14 family) member 1; Carboxypeptidase X member 1; CPX 1; CPX1; CPXM 1; CPXM1; Metallocarboxypeptidase CPX 1; Probable carboxypeptidase X1; CPXM1_HUMAN.  
Research Area Cell biology  immunology  Signal transduction  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 80kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human CPXM
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
CPXM (carboxypeptidase X, member 1) belongs to the peptidase M14 family. However, no carboxypeptidase activity has yet been detected. It may be involved in cell-cell interactions.Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. Belonging to the N/E subfamily, CPXM (metallocarboxypeptidase CPX-1) is a 734 amino acid protein that contains a F5/8 type C domain and likely binds one zinc ion per subunit. Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide, and are thought to function mostly in protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway. CPXM is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily. Studies showing that CPXM expression is regulated during osteoclastogenesis suggest that CPXM may play a role in osteoclast differentiation. There are two isoforms of CPXM which are a result of alternative splicing events.

Function:
May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Subcellular Location:
Secreted (By similarity).

Similarity:
Belongs to the peptidase M14 family.
Contains 1 F5/8 type C domain.

Database links:
UniProtKB/Swiss-Prot: Q96SM3.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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