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Rabbit Anti-NAP1L2/APC Conjugated antibody
Rabbit Anti-NAP1L2/APC Conjugated antibody
Brain specific gene BPX; BPX; Brain specific protein, X linked; MGC26243; Nucleosome assembly protein 1 like 2; NP1L2_HUMAN.
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  • NO.:SL11172R-APC
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Dog,Pig,Horse,Rabbit,)
    Applications:ICC IF
    concentration:1mg/ml
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Details

Product Name Anti-NAP1L2/APC
Chinese Name APC标记的脑特异性蛋白BPX抗体
Alias Brain specific gene BPX; BPX; Brain specific protein, X linked; MGC26243; Nucleosome assembly protein 1 like 2; NP1L2_HUMAN.  
Research Area Chromatin and nuclear signals  Neurobiology  Cell adhesion molecule  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 53kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human NAP1L2
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Proper nucleosome assembly is critical for compacting DNA into chromatin. In human and mouse there are 5 protein-coding genes which comprise the nucleosome assembly protein (NAP) family. NAP1L1 (NAP1) and NAP1L4 (NAP2) are ubiquitously expressed family members which have been the most extensively studied. The remaining three family members, NAP1L2, NAP1L3 and NAP1L5 are neuron-specific nucleosome assembly proteins translated from intronless genes which are monoallelically expressed. NAP1L2 (nucleosome assembly protein 1-like 2), also known as BPX (brain specific protein, X-linked), is a 460 amino acid protein containing acidic domains which are thought to mediate histone interactions. NAP1L2 binds to chromatin and interacts with Histones H3 and H4. The function of NAP1L2 is not clearly defined although evidence suggests that NAP1L2 influences histone acetylation and therefore may play a significant role in regulating transcription in developing neurons.

Function:
NAP1L2 is a member of the nucleosome assembly protein (NAP) family.

Subcellular Location:
Nuclear

Similarity:
Belongs to the nucleosome assembly protein (NAP) family.

Database links:
UniProtKB/Swiss-Prot: Q9ULW6.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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