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Rabbit Anti-HOXA7/APC Conjugated antibody
Rabbit Anti-HOXA7/APC Conjugated antibody
ANTP; Homeobox A7; Homeobox protein Hox 1.1; Homeobox protein Hox A7; Homeobox protein Hox-1A; Homeobox protein Hox-A7; HOX1; Hox1A; HOXA7; HXA7_HUMAN.
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  • NO.:SL11295R-APC
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,Mouse,Rat,(predicted: Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)
    Applications:ICC IF
    concentration:1mg/ml
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Details

Product Name Anti-HOXA7/APC
Chinese Name APC标记的同源盒基因HOXA7蛋白抗体
Alias ANTP; Homeobox A7; Homeobox protein Hox 1.1; Homeobox protein Hox A7; Homeobox protein Hox-1A; Homeobox protein Hox-A7; HOX1; Hox1A; HOXA7; HXA7_HUMAN.  
Research Area Cardiovascular  Cell biology  Neurobiology  transcriptional regulatory factor  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 25kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human HOXA7
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
HOX genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene Hoxa-1 is transcriptionally regulated by retinoic acid (RA) and encodes a transcription factor, which has been shown to play important roles in cell differentiation and embryogenesis. Hoxa-1 is also expressed in cancers, such as mammary tumors, though it is not expressed in normal gland or in precancerous mammary tissues. At embryonic stages, Hoxa-2 is expressed in the mesenchyme and epithelial cells of palate, however its expression is restricted to the tips of the growing palatal shelves. Hoxa-2 protein is predominantly expressed in the nuclei of cells in the ventral mantle region of the developing embryo. In the developing and adult mouse spinal cord, Hoxa-2 protein may contribute to dorsal-ventral patterning and/or to the specification of neuronal phenotype. Hoxa-7 functions as a potent transcriptional repressor and its action as such requires several domains, including both activator and repressor regions. Hoxa-7 is expressed in the fetal liver, lung, skeletal muscle, kidney, pancreas and placenta.

Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Location:
Nucleus.

DISEASE:
Belongs to the Antp homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 3204 Human

Entrez Gene: 500126 Rat

Omim: 142950 Human

SwissProt: P31268 Human

SwissProt: P09634 Rat

Unigene: 610216 Human

Unigene: 660918 Human

Unigene: 203714 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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