Product Name	Anti-GNAT2/APC
Chinese Name	APC标记的G蛋白转录因子α2/Gα t2抗体
Alias	ACHM4; Cone type transducin alpha subunit; GNAT 2; GNAT C; Gnat2; GNAT2_HUMAN; GNATC; Guanine nucleotide binding protein (G protein) alpha transducing; polypeptide 2; Guanine nucleotide binding protein G t subunit alpha 2; Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha 2; Transducin alpha-2 chain; Transducin alpha2; Transducin cone specific alpha polypeptide.
Research Area	Neurobiology  Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	40kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GNAT2 (2-100aa)
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Tissue Specificity: Retinal rod outer segment. DISEASE: Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4) [MIM:139340]. Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination. Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily. Database links: Entrez Gene: 2780 Human Entrez Gene: 14686 Mouse Entrez Gene: 365901 Rat Omim: 139340 Human SwissProt: P19087 Human SwissProt: P50149 Mouse Unigene: 36973 Human Unigene: 439652 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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