Product Name	Anti-THOP1/APC
Chinese Name	APC标记的Thimet内肽酶抗体
Alias	Thimet Oligopeptidase; Endopeptidase 24.15; EP24.15; MEPD_HUMAN; MP78; Thimet oligopeptidase 1; Thop1; THOP1_HUMAN; EC 3.4.24.15.
Research Area	Cell biology  Neurobiology  Alzheimer's
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	79kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Thimet Oligopeptidase
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Thimet oligopeptidase, also designated soluble metallo-endopeptidase, is a cytoplasmic protein belonging to the peptidase M3 family. The gene for the protein maps against chromosome 19q13.3. Thimet oligopeptidase can degrade the b-Amyloid precursor protein and generate amyloidogenic fragments. It is important in cytoplasmic peptide degradation and involved in metabolism of neuropeptides that are less than 20 amino acids in length. Thimet oligopeptidase is highly expressed in testis but can also be detected in liver, lung and kidney. Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. Subunit: Monomer. Subcellular Location: Cytoplasm. Similarity: Belongs to the peptidase M3 family. Database links: Entrez Gene: 7064 Human Entrez Gene: 50492 Mouse Entrez Gene: 64517 Rat Omim: 601117 Human SwissProt: P52888 Human SwissProt: Q8C1A5 Mouse SwissProt: P24155 Rat Unigene: 78769 Human Unigene: 26995 Mouse Unigene: 9490 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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