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Mouse Anti-HBeAg (2E9)/AF594 Conjugated antibody
Mouse Anti-HBeAg (2E9)/AF594 Conjugated antibody
Hepatitis B Virus E Antigen; HBe antigen; HBeAg; HBVgp4; Pre C,C; Precore protein; Precore/core; Precore/core ORF; Precore/core protei; HBEAG_HBVD3; External core antigen; HBeAg; p25.
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Details

Product Name Anti-HBeAg (2E9)/AF594
Chinese Name AF594标记的人乙型肝炎e抗原单克隆(包被)抗体
Alias Hepatitis B Virus E Antigen; HBe antigen; HBeAg; HBVgp4; Pre C,C; Precore protein; Precore/core; Precore/core ORF; Precore/core protei; HBEAG_HBVD3; External core antigen; HBeAg; p25.  
Research Area immunology  Bacteria and viruses  
Immunogen Species Mouse
Clonality Monoclonal
Clone NO. 2E9
React Species
Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 18kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen HBeAg full length protein
Lsotype IgG
Purification affinity purified by Protein G
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Hepatitis B e-antigen (HBeAg) is a viral protein associated with HBV infections. Unlike the surface antigen, the e-antigen is found in the blood only when there are viruses also present. When the virus goes into “hiding,” the e-antigen will no longer be present in the blood. HBeAg is often used as a marker of ability to spread the virus to other people (infectivity). Measurement of e-antigen may also be used to monitor the effectiveness of HBV treatment; successful treatment will usually eliminate HBeAg from the blood and lead to development of antibodies against e-antigen (anti-HBe). There are some types (strains) of HBV that do not make e-antigen; these are especially common in the Middle East and Asia. In areas where these strains of HBV are common, testing for HBeAg is not very useful.

Function:
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells. This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.

Subunit:
Homodimerizes.

Subcellular Location:
Secreted. Host nucleus.

Post-translational modifications:
Phosphorylated.
Cleaved by host furin.

Similarity:
Belongs to the orthohepadnavirus precore antigen family.

Database links:

Entrez Gene: 944568 Hepatitis B virus

SwissProt: Q89714 Hepatitis B virus



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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UsernameQuantitybought time
Ta***12024-07-26
Na***12024-07-14
Mi***22024-05-14
La***22024-04-27
Et***22023-08-19
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