Product Name	Anti-Ubiquitin/AF350
Chinese Name	AF350标记的Ubiquitin蛋白抗体
Alias	FLJ25987; MGC8385; RPS27A; RPS 27A; UBA52; UBA 52; UBA80; UBA 80; UBB; UBC; UB; UBCEP1; UBCEP2; UBCEP 1; UBCEP 2; UBCEP-1; UBCEP-2; Ubiquitin; ubiquitin B; UBC_HUMAN; UBB_HUMAN; RS27A_HUMAN; HMG20; Ubiquitin carboxyl extension protein 80; Ubiquitin; Polyubiquitin-C; Polyubiquitin-B.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Apoptosis  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Pig, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	8.5kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Ubiquitin N-terminuse
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the ubiquitin family. Contains 9 ubiquitin-like domains. Database links: Entrez Gene: 281370 Cow Entrez Gene: 100049794 Horse Entrez Gene: 7314 Human Entrez Gene: 22187 Mouse Entrez Gene: 192255 Rat Omim: 191339 Human SwissProt: P0CG53 Cow SwissProt: Q8MKD1 Horse SwissProt: P0CG47 Human SwissProt: P0CG48 Human SwissProt: P62988 Human SwissProt: P0CG49 Mouse SwissProt: P62991 Mouse SwissProt: P0CG51 Rat SwissProt: P62989 Rat Unigene: 356190 Human Unigene: 520348 Human Unigene: 282093 Mouse Unigene: 371592 Mouse Unigene: 110618 Rat Unigene: 1253 Rat Unigene: 3761 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Ubiquitin及类Ubiquitin蛋白(Ubls) 存在在多种细胞中，有多种细胞调控的功能，如细胞增殖、凋亡、细胞周期及DNA修复等。但Ubiquitin途径的异常会导致人类疾病的产生，包括多种形式的Tumour的发生，神经退变等都与Ubiquitin有关。 相关产品： Ubiquitin 1-76 peptides (SL10803P);

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