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Product Name phospho-Girdin (Tyr1765) Chinese Name 磷酸化GirdinRecombinant rabbit monoclonal anti Alias GIV (pY1765); Girdin (phospho Y1765); p-Girdin (phospho Y1765); GRDN_HUMAN; CCDC88A; APE; GRDN; KIAA1212; Akt phosphorylation enhancer (APE); Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein (GIV); Girders of actin filament; Hook-related protein 1 (HkRP1); 肌动蛋白Binding proteinGirdin; Product Type Phosphorylated anti Recombinant rabbit monoclonal anti Research Area Neurobiology Signal transduction Cell adhesion molecule Immunogen Species Rabbit Clonality Monoclonal Clone NO. G5F7 React Species Human, Mouse, Rat, Applications IHC-P=1:1000 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 206kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human APE around the phosphorylation site of Ser1765: DT(p-Y)FI Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
SWISS:
Q3V6T2
Gene ID:
55704
Database links:Entrez Gene: 55704 Human
Entrez Gene: 108686 Mouse
SwissProt: Q3V6T2 Human
SwissProt: Q5SNZ0 Mouse
Product Picture Tissue:Rat stomach
Section type: Formalin fixed & Paraffin -embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000
Primary ab incubation condition: 1 hour at room temperature
Counter stain: Hematoxylin
Comment: Color brown is the positive signal for SLM-60279R
Tissue:Human breast cancer
Section type: Formalin fixed & Paraffin -embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000
Primary ab incubation condition: 1 hour at room temperature
Counter stain: Hematoxylin
Comment: Color brown is the positive signal for SLM-60279R
Tissue:Rat liver
Section type: Formalin fixed & Paraffin -embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000
Primary ab incubation condition: 1 hour at room temperature
Counter stain: Hematoxylin
Comment: Color brown is the positive signal for SLM-60279R
Tissue:Mouse stomach
Section type: Formalin fixed & Paraffin -embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000
Primary ab incubation condition: 1 hour at room temperature
Counter stain: Hematoxylin
Comment: Color brown is the positive signal for SLM-60279R
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