Product Name	ZDHHC20
Chinese Name	锌指结构蛋白酶20抗体
Alias	DHHC-20; Probable palmitoyltransferase ZDHHC20; ZDH20_HUMAN; ZDHHC20; Zinc finger DHHC domain-containing protein 20.
Research Area	Cell biology  Channel protein  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DHHC-20: 241-365/365
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC20 (zinc finger, DHHC-type containing 20) is a 365 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger and is thought to function as a palmitoyltransferase, catalyzing the transformation of palmitoyl-CoA and a cysteine-conjugated protein to an S-palmitoyl protein and free CoA. In response to DNA damage, ZDHHC20, which exists as multiple alternatively spliced isoforms, may be phosphorylated by ATM or ATR. The gene encoding ZDHHC20 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Function: Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger. SWISS: Q5W0Z9 Gene ID: 253832 Database links: Entrez Gene: 253832 Human Entrez Gene: 75965 Mouse Entrez Gene: 305923 Rat SwissProt: Q5W0Z9 Human SwissProt: Q5Y5T1 Mouse Unigene: 564611 Human Unigene: 29044 Mouse Unigene: 22849 Rat
Product Picture	Sample: HL60(Human) Cell Lysate at 30 ug Primary: Anti- ZDHHC20 (SL7418R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 44 kD

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