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Product Name HLA DM Chinese Name 组织相容性复合体α抗体 Alias Class II histocompatibility antigen M alpha chain; D6S222E; DMA; HLA class II histocompatibility antigen DM alpha chain; HLA DMA; HLADM; Major histocompatibility complex class II DM alpha; MHC class II antigen DMA; Really interesting new gene 6 protein; Ring 6; Ring6; DMA_HUMAN. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 26kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HLA DM: 101-200/261 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing. HLA DM plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.
Subunit:
Heterodimer of an alpha chain (DMA) and a beta chain (DMB).
Subcellular Location:
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the MHC class II family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
SWISS:
P28067
Gene ID:
3108
Database links:
UniProtKB/Swiss-Prot: P28067.1
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