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Product Name CRR9 Chinese Name 顺氯氨铂耐药相关蛋白9抗体 Alias Cisplatin resistance related protein 9; Cisplatin resistance related protein CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1 like protein; Cleft lip and palate transmembrane protein 1-like protein; CLP1L_HUMAN; CLPTM1 like; CLPTM1 like protein; CLPTM1-like protein; CLPTM1L; CRR9; CRR9p. Research Area Tumour Cell biology Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 62kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CLPTM1L/CRR9: 165-270/538 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate and the hard palate. Cleft lip (with or without cleft palate) is a genetically complex birth defect that occurs in approximately one in every 750-1,000 live births. This is one of the most common birth defects and is multifactorial, with both genetic and environmental causes. Cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) belongs to a family of cleft lip and palate transmembrane proteins. This family also contains cisplatin resistance-related protein (CRR9), which is involved in CDDP-induced apoptosis. CLPTM1L (cleft lip and palate transmembrane protein 1-like protein), also known as CRR9p (cisplatin resistance-related protein 9) is a 538 amino acid multi-pass membrane protein that belongs to the CLPTM1 family and, when overexpressed, enhances cisplatin-mediated apoptosis. CLPTM1L exists as two alternatively spliced isoforms encoded by a gene that maps to human chromosome 5p15.33.
Function:
Enhances cisplatin-mediated apoptosis, when overexpressed.
Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).
Similarity:
Belongs to the CLPTM1 family
SWISS:
Q96KA5
Gene ID:
81037
Database links:Entrez Gene: 81037 Human
Omim: 612585 Human
SwissProt: Q96KA5 Human
Unigene: 444673 Human
顺氯氨铂属于细胞周期非特异性药物,具有细胞毒性,可抑制癌细胞的DNA复制过程,并损伤其The cell membrane上结构,有较强的广谱抗癌作用。临床用于卵巢癌、前列腺癌、睾丸癌、肺癌、鼻咽癌、食道癌、恶性淋巴瘤、乳腺癌、头颈部鳞癌、甲状腺癌及成骨肉瘤等多种实体Tumour均能显示疗效。
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