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Product Name SDF4 Chinese Name 基质细胞衍生因子4抗体(钙Binding protein) Alias CAB45; Calcium binding protein; PSEC0034; SDF 4; SDF-4; Stromal cell derived factor 4; CAB45_HUMAN. Research Area Tumour Cell biology Signal transduction Growth factors and hormones Binding protein TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 38kDa Cellular localization cytoplasmic The cell membrane Extracellular matrix Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SDF4: 121-230/362 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011].
Function:
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment (By similarity).
Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. [COFACTOR] Binds calcium (By similarity). Isoform 5 binds calcium.
Subunit:
Isoform 5 interacts with STXBP1; the interaction is enhanced in presence of calcium. Isoform 5 interacts with STX3.
Subcellular Location:
Isoform 1: Golgi apparatus lumen (By similarity).
Isoform 5: Cytoplasm. Cell projection, bleb. Note=Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs.
Tissue Specificity:
Ubiquitous. Isoform 5 is expressed in pancreas.
Similarity:
Belongs to the CREC family.
Contains 6 EF-hand domains.
SWISS:
Q9BRK5
Gene ID:
51150
Database links:Entrez Gene: 51150 Human
Entrez Gene: 20318 Mouse
Omim: 614282 Human
SwissProt: Q9BRK5 Human
SwissProt: Q61112 Mouse
Unigene: 42806 Human
Unigene: 293517 Mouse
Unigene: 12964 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SDF4) Polyclonal Antibody, Unconjugated (SL6732R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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