Product Name	Insig2
Chinese Name	胰岛素诱导基因2抗体
Alias	Hypothetical protein INSIG2; INSIG 2; INSIG-2; INSIG 2 membrane protein; INSIG2 membrane protein; Insulin induced gene 2; Insulin induced gene 2 protein; Insulin induced protein 2; MGC26273; INSI2_HUMAN.
Research Area	Signal transduction  transcriptional regulatory factor  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Insig2: 65-160/225
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Insig2 is highly similar to the protein product encoded by gene Insig1. Both Insig1 protein and Insig2 protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. Subunit: Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Similarity: Belongs to the INSIG family. SWISS: Q9Y5U4 Gene ID: 51141 Database links: Entrez Gene: 51141 Human Entrez Gene: 72999 Mouse Entrez Gene: 288985 Rat Omim: 608660 Human SwissProt: Q9Y5U4 Human SwissProt: Q91WG1 Mouse SwissProt: Q80UA9 Rat Unigene: 7089 Human Unigene: 27136 Mouse Unigene: 486216 Mouse Unigene: 16736 Rat
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-Insig2 (SL6625R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution Predicted band size: 25 kD Observed band size: 23 kD

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