Product Name	TMPRSS4
Chinese Name	膜型丝氨酸蛋白酶2抗体
Alias	MT SP2; Membrane type serine protease 2; TMPRSS 4; TMPRSS3; Transmembrane protease, serine 4; Transmembrane serine protease 3; UNQ776/PRO1570; TMPS4_HUMAN.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TMPRSS4: 84-130/437 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TMPRSS4 is a member of the peptidase S1 family and contains 1 LDL receptor class A domain, 1 peptidase S1 domain and 1 SRCR domain. It is a probable membrane protease capable of activating ENaC and may process sodium channels in endothelial cells. TMPRSS4 is overexpressed in thyroid neoplasms, and splice variants in TMPRSS4 are thought to be linked with different cancers. Three named isoforms are produced by alternative splicing. Function: Probable protease. Seems to be capable of activating ENaC. Subcellular Location: Membrane; Single-pass type II membrane protein (Potential). Tissue Specificity: High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract. Similarity: Belongs to the peptidase S1 family. Contains 1 LDL-receptor class A domain. Contains 1 peptidase S1 domain. Contains 1 SRCR domain. SWISS: Q9NRS4 Gene ID: 56649 Database links: Entrez Gene: 451581 Chimpanzee Entrez Gene: 489387 Dog Entrez Gene: 101147411 Gorilla Entrez Gene: 100071190 Horse Entrez Gene: 56649 Human Entrez Gene: 100390415 Marmoset (common) Entrez Gene: 100436934 Orangutan Omim: 606565 Human SwissProt: Q9NRS4 Human Unigene: 161985 Human
Product Picture	Sample:Epithelium (Mouse)Lysate at 40 ug Primary: Anti-TMPRSS4(SL6286R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 48kD Observed band size: 60kD Sample:A431 (Human)Cell Lysate at 40 ug Primary: Anti-TMPRSS4(SL6286R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 48kD Observed band size: 55kD

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