Product Name	LUCA15
Chinese Name	Tumour抑制基因LUCA15抗体
Alias	G15 antibody H37 antibody LUCA 15; LUCA15; Protein G15; RBM 5; Renal carcinoma antigen NY REN 9; RMB 5; RMB5; RNA binding motif protein 5; RNA binding protein 5; Tumor suppressor LUCA15; RBM5_HUMAN.
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	92kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RBM5/LUCA15: 731-815/815
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	RBM5 (RNA binding motif protein 5) is a nuclear SR related RNA binding protein which specifically binds poly(G) RNA homopolymers in vitro. It modulates both apoptosis and the cell cycle, and retards tumor formation. Subunit: Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect. Subcellular Location: Nuclear. Tissue Specificity: Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines. Similarity: Belongs to the RBM5/RBM10 family. Contains 1 C2H2-type zinc finger. Contains 1 G-patch domain. Contains 1 RanBP2-type zinc finger. Contains 2 RRM (RNA recognition motif) domains. SWISS: P52756 Gene ID: 10181 Database links: Entrez Gene: 10181 Human Entrez Gene: 83486 Mouse Entrez Gene: 300996 Rat Omim: 606884 Human SwissProt: Q1RMU5 Cow SwissProt: P52756 Human SwissProt: Q91YE7 Mouse SwissProt: B2GV05 Rat Unigene: 439480 Human Unigene: 259197 Mouse Unigene: 17033 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat thyroid gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LUCA15) Polyclonal Antibody, Unconjugated (SL6090R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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