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Product Name ADAM11 Chinese Name 去整合素样金属蛋白酶11抗体 Alias A disintegrin and metalloproteinase domain 11; ADA11_HUMAN; MDC; Metalloproteinase like, disintegrin like, and cysteine rich protein. Research Area Tumour Cell biology immunology Neurobiology Signal transduction Cytoskeleton Extracellular matrix Ubiquitin Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 60kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ADAM11: 351-450/769 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008].
Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
Subunit:
Can bind to LGI1 and LGI4.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed predominantly in brain. Slightly detected or not at all in other tissues.
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase.
Similarity:
Contains 1 disintegrin domain.
Contains 1 EGF-like domain.
Contains 1 peptidase M12B domain.
SWISS:
O75078
Gene ID:
4185
Database links:Entrez Gene: 4185 Human
Omim: 155120 Human
SwissProt: O75078 Human
Unigene: 6088 Human
Extracellular matrix蛋白Product Picture Sample: A549 Cell (Human) Lysate at 40 ug
Primary: Anti-ADAM11 (SL5846R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 60 kD
Observed band size: 60 kD
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