Product Name	HEPACAM
Chinese Name	肝Cell adhesion molecule抗体
Alias	GlialCAM; HECAM_HUMAN; HEPACAM; Hepatocyte cell adhesion molecule; Protein hepaCAM.
literatures	Specific References  (1)     |     SL5840R has been referenced in 1 publications. [IF=4.88] Maes, Michaël, et al. "Involvement of connexin43 in acetaminophen-induced liver injury." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease (2016).  Mouse.   PubMed:26912412
Research Area	Tumour  immunology  Signal transduction  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	cytoplasmic The cell membrane Extracellular matrix
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HEPACAM: 101-200/416 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation. Subunit: Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface. Subcellular Location: Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=In MCF7 breast carcinoma and hepatic Hep3B and HepG2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q14CZ8 Gene ID: 220296 Database links: Entrez Gene: 220296 Human Entrez Gene: 72927 Mouse Omim: 611642 Human SwissProt: Q14CZ8 Human SwissProt: Q640R3 Mouse Unigene: 159863 Human Unigene: 266133 Mouse
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug U87MG(Human) Cell Lysate at 30 ug Primary: Anti- HEPACAM (SL5840R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 62 kD Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HEPACAM) Polyclonal Antibody, Unconjugated (SL5840R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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