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Product Name CCDC106 Chinese Name 卷曲螺旋结构域蛋白106抗体 Alias Ccdc106; Coiled-coil domain-containing protein 106; Protein predicted by clone 23882; ZNF581; CC106_HUMAN. Research Area Tumour Cell biology immunology Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, (predicted: Dog, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 31kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CCDC106: 201-280/280 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Function:
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Subunit:
Interacts with p53/TP53.
Subcellular Location:
Nucleus. Note=Colocalizes with p53/TP53.
SWISS:
Q9BWC9
Gene ID:
29903
Database links:Entrez Gene: 29903 Human
Entrez Gene: 232821 Mouse
Omim: 613478 Human
SwissProt: Q9BWC9 Human
SwissProt: Q3ULM0 Mouse
Unigene: 82482 Human
Unigene: 482157 Mouse
Unigene: 488775 Mouse
CCDC106通过与p53蛋白相互作用,促进p53蛋白的降解,导致p53功能失活。CCDC106基因很可能是一个癌基因,CCDC106的高表达可能是导致具有野生型p53Tumour发生的原因之一。Product Picture Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti- CCDC106 (SL5711R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD
Sample:
A549(Human) Cell Lysate at 30 ug
Primary: Anti- CCDC106 (SL5711R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCDC106) Polyclonal Antibody, Unconjugated (SL5711R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCDC106) Polyclonal Antibody, Unconjugated (SL5711R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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