Product Name	ORP150
Chinese Name	氧气调节蛋白150抗体
Alias	150 kDa oxygen regulated protein; 150 kDa oxygen-regulated protein; 170 kDa glucose regulated protein; 170 kDa glucose-regulated protein; DKFZp686N08236; FLJ94899; FLJ97572; glucose regulated protein 170; Grp 170; GRP-170; Grp170; HSP 12A; HSP12A; Hyou1; HYOU1_HUMAN; Hypoxia up regulated 1; hypoxia up-regulated 1 precursor; Hypoxia up-regulated protein 1; Hypoxia upregulated 1; Orp 150; ORP-150; Orp150; oxygen regulated protein (150kD).
literatures	Specific References  (1)     |     SL4248R has been referenced in 1 publications. [IF=2.12] Ruan Lin, et al. "Tetrandrine Attenuated Cerebral Ischemia/Reperfusion Injury and Induced Differential Proteomic Changes in a MCAO Mice Model Using 2-D DIGE." Neurochemical Research (2013). 1-9.  WB ;  Rat.   PubMed:23780673
Research Area	Tumour  Cardiovascular  immunology  Chromatin and nuclear signals  Neurobiology  Signal transduction  The new supersedes the old  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	108kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ORP150: 401-500/999
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ORP150 (150KDa Oxygen-regulated Protein) is a member of the heat shock protein/stress protein family and has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. This protein has also been described as a molecular chaperone, induced by various environmental and physiological stimuli, and participates in protein folding in the endoplasmic reticulum. Furthermore, ORP150 is up-regulated in tumors and, in breast tumors, may be associated with tumor invasiveness. Function: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Subunit: Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Subcellular Location: Endoplasmic reticulum lumen. Tissue Specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. Similarity: Belongs to the heat shock protein 70 family. SWISS: Q9Y4L1 Gene ID: 10525 Database links: Entrez Gene: 10525 Human Entrez Gene: 12282 Mouse Entrez Gene: 192235 Rat Omim: 601746 Human SwissProt: Q9Y4L1 Human SwissProt: Q9JKR6 Mouse SwissProt: Q63617 Rat Unigene: 277704 Human
Product Picture	Sample: Pancreas (Mouse) Lysate at 40 ug Primary: Anti- ORP150 (SL4248R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 108 kD Observed band size: 108 kD

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