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Product Name Claudin 4 Chinese Name 紧密连接蛋白4抗体 Alias CLDN 4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPE R; CPE receptor; CPER; CPETR 1; CPETR; CPETR1; hCPE R; WBSCR8; Williams Beuren syndrome chromosome region 8 protein; Claudin-4; CLD4_HUMAN; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor. literatures Specific References (5) | SL2790R has been referenced in 5 publications.[IF=7.727] Xue Wang. et al. Engineered liposomes targeting the gut–CNS Axis for comprehensive therapy of spinal cord injury. J Control Release. 2021 Mar;331:390 WB ; Human.[IF=4.171] Chuanqi Wang. et al. Exposure to oxidized soybean oil induces mammary mitochondrial injury in lactating rats and alters the intestinal barrier function of progeny. 2021 Mar 15 WB ; Rat.[IF=3.68] Wang, Tao, et al. "Notch inhibition promotes fetal liver stem/progenitor cells differentiation into hepatocytes via the inhibition of HNF-1β." Cell and Tissue Research (2014): 1-12. WB ; Rat.[IF=3.531] Yanan Gao. et al. Aflatoxin B1 and Aflatoxin M1 Induce Compromised Intestinal Integrity through Clathrin-Mediated Endocytosis. Toxins. 2021 Mar;13(3):184 WB,IF ; Mouse, Human.[IF=2.276] Y D et al. ROS Plays a Role in the Neonatal Rat Intestinal Barrier Damages Induced by HyperoxiaBiomed Res Int.2020 Dec 26;2020:8819195. WB ; Rat、Human.Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:2000-5000 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CLDN4: 21-120/209 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact made up of network of strands that act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.
Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions.
Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the claudin family.
SWISS:
O14493
Gene ID:
1364
Database links:Entrez Gene: 1364 Human
Entrez Gene: 12740 Mouse
Omim: 602909 Human
SwissProt: O14493 Human
SwissProt: O35054 Mouse
Unigene: 647036 Human
Unigene: 699253 Human
Unigene: 7339 Mouse
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