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Product Name IL22BP Chinese Name 白介素22受体Binding protein抗体 Alias IL22RA2; Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Interleukin-22-binding protein; IL-22BP; IL22BP; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor class-II member 10; Cytokine receptor family type 2, soluble 1; CRF2-S1; ZcytoR16; I22R2_HUMAN. literatures Specific References (2) | SL2625R has been referenced in 2 publications.[IF=4.087] Wang, Xiaobai. et al. Relationship between IL-22 and IL-22BP in diabetic cognitive dysfunction. ACTA DIABETOL. 2023 Jan;:1-14 WB ; Mouse.[IF=0] Almishri, Wagdi. Regulatory Immune-Responses Occurring within the Liver Downstream of Hepatic iNKTcell activation. Diss. University of Calgary, 2015. IHC-P ; Mouse.Research Area immunology Cell Surface Molecule Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28(hu)/25(mo, rakDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IL-22BP: 165-263/263 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail There are two isoforms of IL22 RA2 produce by alternative splicing. Isoform 1 may play a role in establishing and maintaining successful pregnancy. Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). It may play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Function:
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.
Similarity:
Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains.
SWISS:
Q969J5
Gene ID:
116379
Database links:Entrez Gene: 116379 Human
Omim: 606648 Human
SwissProt: Q969J5 Human
Unigene: 126891 Human
白介素22Binding protein是一种新型的Ⅱ类cell factor受体家族成员,它能直接结合IL-22,作为IL-22的拮抗剂,发挥着多种生物学功能。Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL22BP) Polyclonal Antibody, Unconjugated (SL2625R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Blank control: mouse spleen sells(blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice.
Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 1μg in 100 μL1X PBS containing 0.5% BSA(green).
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