Product Name	IL22R
Chinese Name	白介素22受体抗体
Alias	IL-22R; CRF2 9; IL22 Receptor Alpha; cytokine receptor classII member 9; cytokine receptor family 2 member 9; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL22R; IL22R1; IL22RA1; ILTIF R1 chain; Interleukin 22 Receptor alpha 1; Interleukin 22 Receptor; Interleukin-22 receptor subunit alpha-1; ZcytoR11; I22R1_HUMAN; IL-22 receptor subunit alpha-1; IL-22RA1; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; CRF2-9.
literatures	Specific References  (8)     |     SL2624R has been referenced in 8 publications. [IF=8.65] Kulkarni et al. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. (2014) J.Am.Soc.Nephrol. 25:978-89  IHC ;  Mouse.   PubMed:24459235 [IF=8.109] Jane A. Lindborg. et al. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Rep. 2021 Mar;34:108777  IHC ;  Mouse.   PubMed:33657370 [IF=6.208] Yanan Hao. et al. Alginate Oligosaccharides Repair Liver Injury by Improving Anti-Inflammatory Capacity in a Busulfan-Induced Mouse Model. INT J MOL SCI. 2023 Jan;24(4):3097  IF ;  Mouse.   PubMed:36834506 [IF=3.061] Wanzhen Li. et al. Ac2-26 attenuates hepatic ischemia-reperfusion injury in mice via regulating IL-22/IL-22R1/STAT3 signaling. PEERJ. 2022 Sep;10:e14086  WB ;  Mouse.   PubMed:36193422 [IF=2.09] Guo, Yujie, et al. "IL-22-producing Th22 cells play a protective role in CVB3-induced chronic myocarditis and dilated cardiomyopathy by inhibiting myocardial fibrosis." Virology Journal 11.1 (2014): 2511.  IHC-P ;  Mouse.   PubMed:25547181 [IF=0] ES Yuksel et al. IL-17 and IL-22 in colitis associated colorectal cancer in mice. Medical Science. 2019 April 11,23(97).  IHC-P ;  Mouse.   PubMed:ISSN:2321–7359 [IF=0] Burgo et al. Ruxolitinib inhibits cyclosporine-induced proliferation of cutaneous squamous cell carcinoma. (2018) JCI.Insight. 3  WB，IHC ;  Human.   PubMed:30185657 [IF=0] Zhang, Yan, and Mikhail G. Kolonin. "Cytokine signaling regulating adipose stromal cell trafficking." Adipocyte 5.4 (2016): 369-374.  IHC-P ;  Mouse.   PubMed:27994950
Research Area	Cell biology  immunology  Signal transduction  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-22R: 41-150/574 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]. Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Subunit: Heterodimer with IL10RB and with IL20RB. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in kidney, liver and lung. Similarity: Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains. SWISS: Q8N6P7 Gene ID: 58985 Database links: Entrez Gene: 58985 Human Omim: 605457 Human SwissProt: Q8N6P7 Human Unigene: 110915 Human
Product Picture	Sample: Lane1: Liver(Mouse) Lysate at 30 ug Lane2: Intestinal(Mouse) Lysate at 30 ug Primary: Anti-IL22R (SL2624R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(SL0295G-HRP) at 1: 5000 dilution; Predicted band size : 61kD Observed band size : 61kD Sample: placenta (Mouse) Lysate at 40 ug Primary: Anti-IL22R (Bs-2624R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kD Observed band size: 65 kD

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