Product Name	IL-22
Chinese Name	白介素-22抗体
Alias	Interleukin-22; Il22; Iltif; ILTIFa; MGC129416; MGC129417; IL-10-related T-cell-derived-inducible factor; IL-TIF; ILTIF; IL-TIF alpha; Interleukin-22a; IL-22a; IL 21; IL D110; IL TIF; IL21; IL22; ILD110; interleukin 21; MGC79382; MGC79384; TIFa; TIFIL 23; TIFIL-23; TIFIL23; zcyto18; Cytokine Zcyto18.
literatures	Specific References  (5)     |     SL2623R has been referenced in 5 publications. [IF=8.755] Jieying Chen. et al. Nestin+ Peyer's patch resident MSCs enhance healing of inflammatory bowel disease through IL-22-mediated intestinal epithelial repair. CELL PROLIFERAT. 2022 Nov;:e13363  WB ;  Mouse.   PubMed:36404603 [IF=3.061] Wanzhen Li. et al. Ac2-26 attenuates hepatic ischemia-reperfusion injury in mice via regulating IL-22/IL-22R1/STAT3 signaling. PEERJ. 2022 Sep;10:e14086  WB ;  Mouse.   PubMed:36193422 [IF=2.09] Huang, Yong-Hong, et al. "Th22 cell accumulation is associated with colorectal cancer development."World Journal of Gastroenterology  IHC-P ;   PubMed:25892871 [IF=1.42] Karaboga, İhsan, Selim Demirtas, and Turan Karaca. "Investigation of the relationship between the Th17/IL-23 pathway and innate-adaptive immune system in TNBS-induced colitis in rats." Iranian Journal of Basic Medical Sciences 20.8 (2017): 870-879.  WB ;  Rat.   PubMed:29085578 [IF=0] Zhang, Yan, and Mikhail G. Kolonin. "Cytokine signaling regulating adipose stromal cell trafficking." Adipocyte 5.4 (2016): 369-374.  IHC-P ;  Mouse.   PubMed:27994950
Research Area	immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-22: 35-179/179
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq]. Function: Cytokine that contributes to the inflammatory response in vivo. Subcellular Location: Secreted. Similarity: Belongs to the IL-10 family. SWISS: Q9GZX6 Gene ID: 50616 Database links: Entrez Gene: 50616 Human Entrez Gene: 50929 Mouse Entrez Gene: 500836 Rat Omim: 605330 Human SwissProt: Q9GZX6 Human SwissProt: Q9JJY9 Mouse Unigene: 287369 Human Unigene: 103585 Mouse Unigene: 195879 Rat IL-22是白介素-10家族的成员,主要是由激活的T lymphocyte产生的一类重要的cell factor,除了在Th17细胞中高表达之外，在NK和NKT等细胞中也有表达,在组织损伤修复以及牛皮癣、肝炎、肺炎、肠炎等慢性炎症中发挥重要作用.IL-22是继IL-6和IL-10之后又一个参与炎症反应和代谢调控的cell factor，IL-22有可能成为干预脂肪肝发生发展的新方法。
Product Picture	Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-IL22 (SL2623R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kD Observed band size: 19 kD Sample: Lane 1: 293T (Human) Cell Lysate at 30 ug Lane 2: A549 (Human) Cell Lysate at 30 ug Primary: Anti-IL22 (SL2623R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 20 kD Observed band size: 18 kD Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL22) Polyclonal Antibody, Unconjugated (SL2623R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining. Blank control(blue): Mouse liver cells(fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody: Rabbit Anti-IL22 antibody(SL2623R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG (orange) ,used under the same conditions. Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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