Product Name	IL5RA
Chinese Name	白介素-5受体α链抗体IL-5Rα
Alias	Interleukin-5 receptor alpha; CD125 antigen; CDw125; HSIL5R3; IL5R; IL-5R; Interleukin 5 Receptor alpha; Interleukin 5 receptor subunit alpha; interleukin 5 receptor type 3; MGC26560; IL5RA; IL-5R alpha; IL5RA_HUMAN.
literatures	Specific References  (3)     |     SL2601R has been referenced in 3 publications. [IF=5.085] Venosa Alessandro. et al. Role of CCR2+ Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium. Front Immunol. 2021 Apr;12:1348  IHC ;  Mouse.   PubMed:33968067 [IF=4.344] Gitto SB et al. Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. Cell Commun Signal. 2020 Jun 17;18(1):95.  ICF&IHC-P ;  Mouse&Human.   PubMed:32552827 [IF=2.55] Chen, Yanyan, et al. "Catalpol alleviates ovalbumin-induced asthma in mice: Reduced eosinophil infiltration in the lung." International Immunopharmacology 43 (2017): 140-146.  WB ;  Mouse.   PubMed:27992791
Research Area	Cell biology  immunology  transcriptional regulatory factor  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	46kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-5R alpha: 11-110/420 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3(IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5(IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. Function: This is the receptor for interleukin-5. The alpha chain binds to IL5. Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on eosinophils and basophils. Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily. SWISS: Q01344 Gene ID: 3568 Database links: Entrez Gene: 3568 Human Entrez Gene: 16192 Mouse Omim: 147851 Human SwissProt: Q01344 Human SwissProt: P21183 Mouse Unigene: 207105 Human Unigene: 68876 Human Unigene: 3448 Mouse
Product Picture	Sample: testis (mouse) Lysate at 40 ug lung (mouse) Lysate at 40 ug ovary (mouse) Lysate at 40 ug A549 (human)cell Lysate at 40 ug Primary: Anti- IL5RA(SL2061R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 46kD Observed band size: 56 kD

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